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Module 2 – Josie King

Read Josie King's story:

https://www.healthleadersmedia.com/clinical-care/josies-story-teaches-hospitals-how-become-safer

Read the following safety techniques for patients:

https://josieking.org/resource-center/#for-caregivers

https://josieking.org/from-the-experts/#patient-safety

  1. Write your feelings about Josie and the culture of hiding mistakes and the approximately 98,000 persons that die each year in America because of medical errors.
  2. Answer the questions as thoroughly and concisely as possible.
    • Be sure to reference any works that you utilize in answering the questions (Be sure that references are in APA format).

    applying ethical principles powerpoint

      Apply ethical principles to your previously selected healthcare topic in an 8–10 slide PowerPoint presentation. 

    Introduction

    As a nurse you must base your decisions on a set of ethical principles and values. Your decisions must be fair, equitable, and defensible. Nursing has a professional Code of Ethics for Nurses to guide ethical behavior. In this assessment, you will apply the four ethical principles to the topic you selected for your Applying Research Skills assessment. Your practice will help you develop a method for formulating ethical decisions.

    Prepare

    For this assessment, you will apply the four ethical principles to your healthcare topic (selected in Assessment 2), explain bias as it relates to your topic, and relate at least one of the Four Spheres of Care. Consider the ethical dilemmas healthcare professionals are faced with in your selected topic. Discuss at least one of the Four Spheres of Care and how it is important to understand the ethics of your topic as it relates to the sphere being discussed. Use the Capella University Library to locate at least two academic peer-reviewed journal articles you can use to support your analysis of the situation.

    Use the four core principles that healthcare professionals need to know and honor when helping patients:

    • Autonomy: To honor the patient's right to make their own decisions.
    • Beneficence: To help the patient advance their own good.
    • Nonmaleficence: To do no harm.
    • Justice: To be fair and treat like cases alike, which will be used to inform your work.

    Select at least one of the Four Spheres of Care and discuss how an understanding of ethics is important as it relates to your chosen Sphere.

    • Wellness, Disease Prevention.
    • Chronic Disease Management.
    • Regenerative/Restorative Care.
    • Hospice/Palliative Care.

    Create Your PowerPoint

    To complete this assessment, do the following:

    • Provide a title slide.
    • Identify the topic you selected (the same one you selected for Assessment 2) and briefly summarize the facts surrounding the topic.
    • Apply each of the four ethical principles to your chosen healthcare issue or topic.
      • Explain on one slide how autonomy plays a role in your healthcare issue.
      • Explain on one slide how beneficence plays a role in your healthcare issue.
      • Explain on one slide how nonmaleficence plays a role in your healthcare issue.
      • Explain on one slide how justice plays a role in your healthcare issue.
    • Explain what role bias plays in your topic, and how it relates to the four ethical principles.
    • Explain how an understanding of ethics is important to at least one of the Four Spheres of Care as it relates to your healthcare issue or topic (slides eight +). Use a separate slide for each Sphere if you select more than one.
    • Include a Conclusion and a Reference slide.

    Do NOT use the speaker notes for this assessment. Provide content within each slide only. Make sure to cite references used in the presentation.

    Academic Requirements

    Your PowerPoint should meet the following requirements:

    • Writing: Produce text with minimal grammar, usage, spelling, and mechanical errors.
      • Your text should be concise.
      • Use bulleted or numbered lists.
    • Sources: Integrate at least two references within the past 3–5 years into your text using APA in-text citations.
    • Length: Include eight to ten slides, which include the title slide and reference slides.
      • You will NOT use the speaker notes in this assessment—only provide information on the slides themselves.
    • References: Use at least two references within the PowerPoint presentation. Visit the BSN Program Library Research Guide for help with research.
    • APA format: Follow current APA guidelines for in-text citation of outside sources in the PowerPoint presentation and also on the reference slide. Visit Evidence and APA for help with APA.

    Example assessment: You may use the Assessment 3 Example [PDF] to give you an idea of what a Proficient or higher rating on the scoring guide would look like.

    Competencies Measured

    By successfully completing this assessment, you will demonstrate your proficiency in the following course competencies and scoring guide criteria:

    • Competency 3: Apply ethical principles and academic standards to the study of healthcare.
      • Explain how autonomy plays a role in an identified healthcare issue.
      • Explain how beneficence plays a role in an identified healthcare issue.
      • Explain how nonmaleficence plays a role in an identified healthcare issue.
      • Explain how justice plays a role in an identified healthcare issue.
      • Explain how an understanding of ethics is important to at least one of the Four Spheres of Care as it relates to a healthcare issue or topic.
    • Competency 4: Describe strategies for overcoming biases in healthcare settings.
      • Explain how biases play a role in an identified healthcare issue, and their relationship to the ethical principles.
    • Competency 5: Write for a specific audience, in an appropriate tone and style, in accordance with Capella writing standards.
      • Integrate into text appropriate use of scholarly sources, evidence, and citation style.
      • Produce slides that are easy to read and error free.

    below i have attached the previous assignment that this powerpoint will be based off of. 

    2

    Assessment 2

    Applying Research Skills: Health Information Privacy

    Omar Rodriguez

    Capella University

    NURS-FPX4000

    Professor Michele Lopez

    09/02/2025

    Health Information Privacy

    Health information privacy is a pressing healthcare issue driven by the widespread use of electronic health records (EHRs) and digital health technologies. According to Carvalho, Bandiera-Paiva, Marques, and Machado (2021), preventing breaches of data and unauthorized access is essential to safeguard patient confidentiality, build trust, and maintain compliance with regulations such as the Health Insurance Portability and Accountability Act (HIPAA) and the General Data Protection Regulation (GDPR). The GDPR, enacted in 2018, introduced strict requirements for organizations that access private data in Health Information Systems (HIS) (Carvalho et al., 2021). This paper will briefly discuss how these regulations are essential, as they directly affect patient safety, organizational accountability, and compliance with patient data standards through annotated bibliographies of three peer-reviewed scholarly articles.

    Professional Relevance

    Nursing is often regarded as one of the most ethical professions. This entails that nurses are morally obligated to advocate for patient rights, securely document within patient records and collaborate with other healthcare professionals while maintaining patient safety and integrity. Nurses are at the forefront of maintaining patient privacy and confidentiality, as they are directly involved in providing patient care and education, have access to all relevant medical records and charts and perform one-to-one activities with patients and families. Acting as a gateway between patients and the entirety of the healthcare system, nurses must ensure to be compliant with patient privacy regulations, such as HIPAA and GDPR (Wu et al., 2023).

    Article Selection Process

    Research on best practices for addressing health information privacy was conducted using Capella University’s library resources, including CINAHL Plus with Full Text, PubMed, and ProQuest Nursing & Allied Health Database. Broad keywords such as “health information privacy, electronic health records, data security, and patient confidentiality” were used to narrow down the number of articles. The search was refined with more specific terms, including cybersecurity, privacy regulations, encryption, and healthcare compliance. These results were then filtered to show only peer-reviewed articles published within the last five years.

    Assessing Credibility and Relevance

    To check the credibility of the articles, the abstracts were reviewed to ensure that the articles went along with the research topic, and only those that meet both the correct content and criteria were selected. The purpose of the articles were clearly defined and in line with the topic of this paper. The authors from the chosen articles have previously published articles for well-known and recognized journals in the world of healthcare. These articles contain strictly factual information cited from other credible sources, studies, etc. For example, Carvalho et al. (2021) conducted a systematic study and published it to the International Journal of Reliable and Quality E-Healthcare, a reputable and widely cited journal. Wu et al. (2023) published their article to World Wide Web, which is a credible journal focusing on scientific and technological innovations, filled with peer-reviewed scholarly articles. Ohaja et al. (2023) submitted their research and article to Cogent Arts & Humanities, a multidisciplinary database with peer-reviewed scholarly journals supported by an international editorial board. To further ensure the quality and relevance of the articles, only journal articles that were peer-reviewed and published within the past three to five years were selected.

    Annotated Bibliography

    Carvalho, M., Bandiera-Paiva, P., Marques, E., & Machado, J. M. (2021). Health information systems (HIS) privacy restrictions for GDPR. International Journal of Reliable and Quality E-Healthcare, 10(2), 4–16. https://doi.org/10.4018/ijrqeh.2021040102 This article described the privacy restrictions of health information systems under the foundation of GDPR. The study focused on the difficulties of executing GDPR guidelines, such as patient consent in healthcare environments. The study also noted that although GDPR can help attain patient confidence, the new system requires many changes in the overall structure of healthcare we already have established. The authors recommended using encryption models and access mechanisms as solutions to compliance issues. This article also pinpointed the differences regarding the flow of health information when patient care is centered at one facility versus requiring transferring to multiple facilities. This article is credible, as it was published in a well-known peer-reviewed journal that focuses on healthcare technologies. The authors of this article are all experienced in the field of healthcare technology and health informatics. This article is valuable for healthcare workers because it shows how privacy regulations directly affect the patients and the care they receive.

    Ohaja, E. U., Ukonu, M. O., Mbamalu, M., & Ezeanwu, R. (2023). COVID-19 information protection: Between information privacy, health secrecy and public safety. Cogent Arts & Humanities, 10(1), 2184463. https://doi.org/10.1080/23311983.2023.2184463 This article discussed health information privacy, specifically during the COVID-19 pandemic in Nigeria. The study focused on how the government’s control of information negatively impacted public trust. The articles’ findings showed that restricted media access to isolation centers led to incomplete coverage and widespread suspicion from the public. The articles concluded that maintaining transparent communication is vital for preserving trust, specifically during a health crisis or pandemic. This study is credible because it was published in a peer-reviewed journal, and its’ authors are scholars that specialize in public health and health data. This study is important for nurses and healthcare workers in general, as it focuses on how important communication and transparency is in the eye of the public. This article will help to remind healthcare workers that they play a key role in maintaining the confidence and trust of the people and ensuring they remain educated as healthcare changes over time.

    Wu, Z., Liu, H., Xie, J., Xu, G., Li, G., & Lu, C. (2023). An effective method for the protection of user health topic privacy for health information services. World Wide Web, 26(6), 3837–3859. https://doi.org/10.1007/s11280-023-01208-5 This article focused mainly on a new and inventive solution for the current issues regarding healthcare security. This study proposed a method for privacy protection for health information services using identity replacement and agent algorithms in cloud-based systems. The model reduces privacy exposure without reducing efficiency, which offered a direct solution for maintaining health data safely and securely. The article provided a more technical perspective that focused on regulatory and social matters regarding health information privacy. This article is credible because it was published by authors with experience and proficiency in healthcare security on the World Wide Web, which is a peer-reviewed journal filled with studies from researchers and authors with expertise in data security and healthcare technologies. The research conducted by the authors of this article is more important for nurses than ever, as it focuses on one of the most important aspects of healthcare, the protection and privacy of their patients’ information.

    Learnings from Research

    The research process for this annotated bibliography highlighted health information privacy as a pressing concern in modern times. It demonstrated how it is more important than ever to ensure patient confidentiality is maintained in modern times where everything is digitalized. Compiling the information for the annotated bibliography, ensuring the formatting was correct, learning the process of discovering specific articles with the correct information, using the correct keywords to narrow down the number of articles and filtering for peer-reviewed articles within the last three to five years reiterated the importance of how important it is to correctly use an online library to conduct research. The combined learnings from the requirements of this essay will prove to be useful for future coursework in this program.

    References

    Carvalho, M., Bandiera-Paiva, P., Marques, E., & Machado, J. M. (2021). Health information systems (HIS) privacy restrictions for GDPR. International Journal of Reliable and Quality E-Healthcare, 10(2), 4–16. https://doi.org/10.4018/ijrqeh.2021040102

    Ohaja, E. U., Ukonu, M. O., Mbamalu, M., & Ezeanwu, R. (2023). COVID-19 information protection: Between information privacy, health secrecy and public safety. Cogent Arts & Humanities, 10(1), 2184463. https://doi.org/10.1080/23311983.2023.2184463

    Wu, Z., Liu, H., Xie, J., Xu, G., Li, G., & Lu, C. (2023). An effective method for the protection of user health topic privacy for health information services. World Wide Web, 26(6), 3837–3859. https://doi.org/10.1007/s11280-023-01208-5

    nursing

    By Day 6 of Week 3

    Read a selection of your colleagues’ posts and respond to at least two of your colleagues on two different days by supporting or expanding on the ideas identified by your colleague or sharing additional perspectives on the issue described by your colleague.

    MS

    Mia Lashonda Smith-August

    Sep 8 5:04pm

    Reply from Mia Lashonda Smith-August

    Nursing values and professional ethics are deeply embedded in the advocacy priorities we uphold for vulnerable populations. Core nursing values such as compassion, respect for human dignity, advocacy, and justice align with the American Nurses Association (ANA) Code of Ethics, which emphasizes the nurse’s responsibility to protect and promote the health of individuals and communities (American Nurses Association, 2015). For example, when advocating for disadvantaged groups, such as older adults in institutional care or underserved minority communities, nurses act on their moral obligation to reduce health inequities (Raghavan, 2025).

    Our nursing values demand that advocacy for vulnerable populations remain central to the professional agenda because failure to act perpetuates structural inequities. Ethical principles such as beneficence and nonmaleficence compel nurses to intervene against systemic barriers to care (Akyol & Küçükgüçlü, 2024). Additionally, the professional duty of justice requires that healthcare access and resources be equitably distributed, especially for those at risk of exclusion (Braveman et al., 2022).

    When comparing the role of law, ethics, and politics in shaping advocacy priorities, ethics arguably exerts the most consistent influence. Laws may lag behind societal needs, and politics can shift based on power dynamics, but nursing ethics provide a stable framework rooted in human rights and professional integrity (Annen, 2025). However, law and politics cannot be ignored, as policies determine funding allocations, regulatory requirements, and access to services. Nurses, therefore, function at the intersection of all three domains, but their ethical commitment is what drives persistent advocacy on behalf of vulnerable groups.

    References

    American Nurses Association. (2015). Code of ethics for nurses with interpretive statements. ANA. https://www.nursingworld.org/coe-view-only

    Annen, H. (2025). Psychological responses to conflict and crisis–Understanding resilience, support mechanisms, and moral strain in times of global turmoil. Frontiers in Public Health, 13, 1684360. https://doi.org/10.3389/fpubh.2025.1684360

    Akyol, M. A., & Küçükgüçlü, Ö. (2024). Nursing and ethics: Addressing ethical problems in older adults’ institutional care. In Nursing and Ethics. Istanbul University Press. https://iupress.istanbul.edu.tr/en/book/hemsirelik-ve-etik/chapter/yaslilik-ve-etik

    Braveman, P., Arkin, E., Proctor, D., Kauh, T., & Holm, N. (2022). Systemic inequities and the ethical imperative for health equity in nursing. American Journal of Nursing, 122(3), 24–32. https://doi.org/10.1097/01.NAJ.0000822400.21521.9b

    Raghavan, M. (2025). Advancing health equity: Nursing’s philosophical, theoretical, and ethical approaches to eliminating health disparities. Asian Journal of Research in Nursing, 21(5), 44–52. https://jagunifiedinternational.in/wp-content/uploads/2025/03/AJRGN-Vol.21-5-Feb-2025.pdf

    Ariane Lopez

    Sep 8 11:15am

    Reply from Ariane Lopez

    Nursing Values and Professional Ethics in Advocacy

    Nursing values and ethics are deeply grounded in the principles of beneficence, justice, respect for human dignity, and advocacy for vulnerable populations. The American Nurses Association (ANA) Code of Ethics highlights the nurse’s responsibility to protect and promote patient rights, particularly for those who face barriers to accessing care (ANA, 2015). When patients experience disparities due to socioeconomic status, immigration status, or lack of insurance, the nursing profession has an ethical obligation to advocate for equity. These values reflect a commitment to compassion, integrity, and justice, ensuring that healthcare delivery responds to the needs of all individuals.

    Why Nursing Values and Ethics Demand It Be on the Agenda

    Our professional values require that disparities in care are not ignored. To remain silent would contradict the nurse’s ethical duty to prevent harm and advocate for justice. Nurses have a unique vantage point at the intersection of healthcare delivery and patient experience, witnessing firsthand the impact of inequities. As such, advocacy is not optional but rather a moral imperative. By elevating these concerns, nurses fulfill their ethical duty to influence policy and improve outcomes for populations at risk (Haddad & Geiger, 2022). This alignment between nursing values and advocacy ensures that vulnerable groups are represented in healthcare reform discussions.

    The Role of Law, Ethics, and Politics in Advocacy

    Law, ethics, and politics each shape the advocacy landscape for vulnerable populations. Law establishes the framework for healthcare delivery, such as Medicaid eligibility, insurance regulations, and licensure requirements. However, laws often lag behind population needs. Ethics motivate nurses to speak on behalf of those who cannot advocate for themselves, reinforcing the professional obligation to protect human dignity. Politics ultimately determines how resources are allocated, which services are funded, and which populations are prioritized. Policy decisions can either mitigate or exacerbate disparities.

    Among these, politics has the greatest impact. While law provides structure and ethics drive advocacy, political decision-making shapes funding and policy reform, directly influencing healthcare access and quality (Williams et al., 2018). For this reason, nurses must engage politically, using their ethical foundation to push for policies that promote equity and justice.

    Thank you,

    Ariane Lopez

    References

    American Nurses Association. (2015). Code of ethics for nurses with interpretive statements. American Nurses Association. https://doi.org/10.1002/nur.21735

    Haddad, L. M., & Geiger, R. A. (2022). Nursing ethical considerations. In StatPearls. StatPearls Publishing. https://doi.org/10.1097/NNA.0000000000001098

    Williams, S. D., Phillips, J. M., & Koyama, K. (2018). Nurse advocacy: Adopting a health in all policies approach. Online Journal of Issues in Nursing, 23(3), 1–15. https://doi.org/10.3912/OJIN.Vol23No03Man02

    By Day 6 of Week 3

    Read a selection of your colleagues’ posts and respond to at least two of your colleagues on two different days by supporting or expanding on the ideas identified by your colleague or sharing additional perspectives on the issue described by your colleague.

    HIM

     

    Happy Physician Practice has purchased a new system that assists providers in creating patient notes and billing encounters from some basic input information. The physicians are excited because the system allows them to create a good note and then use it to paste into other encounters and edit. The billing manager is excited, and the entire office is happy about this discovery.

    As the HIM professional what is the most appropriate response?

    Please read chapter 4 and search the internet, AHIMA website resources to support your discussion.

    • The initial response must be relevant, detailed, and specific, at least 250 words.

      Adv. Roles Module 3

      Discuss a nursing model that would be most appropriate to your future advanced nursing practice role. 

      Post your initial discussion by 11:59 PM ET on Thursday. Posts are a minimum of 250 words, scholarly written, APA formatted (with some exceptions due to limitations in the D2L editor), and a minimum of 2 references (which may include the course textbook). Reply to at least one classmate's initial discussion post by Saturday at 11:59 PM ET. The initial discussion post and discussion response should occur on two different calendar days of each electronic week. These are not the complete instructions for participating in discussions. See the "Grading Rubric for Online Discussions – 500 level" found in the Course Resources module.

        Adv. pharm WK 3

        Must post first.

        The pharmacology of men’s and women’s health is a dynamic and evolving field that requires a nuanced understanding of gender-specific physiological and pathological differences. Clinicians must integrate pharmacokinetic and pharmacodynamic principles with individual patient characteristics to optimize therapeutic outcomes (prevention, diagnosis, and treatment of various health issues) and enhance the quality of life for both men and women. . Understanding the pharmacology of gender-specific health involves a comprehensive look at hormonal influences, reproductive health, and the management of gender-specific diseases.

        Consider the following scenarios:

        1) LW is a 32 year old female patient who comes to your medical clinic for primary care.  She has been on hormonal contraceptives for years, although she's just been married and has stopped her pills in hopes of becoming pregnant.  Her PMHx includes obesity, HTN (diagnosed 3 years ago), familial hypercholesterolemia, and pre-diabetes.  Her current medications are as follows: Metformin 1000 mg PO twice daily, Lisinopril 10 mg PO daily, rosuvastatin 5 mg PO daily, and a multivitamin.

        3) GD is an 82-year-old patient is taking 2 mg of terazosin for BPH who comes in complaining of dizziness, generalized muscle weakness and persistent LUTS. He also inquires if the terazosin will prevent "his prostate from getting any bigger and the disease from progressing" as he recently found out his PSA was elevated and prostate is 40cc in size (nl ~ 20 to 30cc).

        Choosing two of the three scenarios above, please discuss:

        • What was the process you went through to assess the current medications?
        • What pharmacotherapy plan (changes to medications, monitoring and follow-up) would you recommend to maximize therapeutic outcomes and enhance the patient's quality of life? 
        • How should you educate these patients regarding their conditions and medications?

        Submit  your completed responses, [MS Word document or equivalent] to the Assignment folder "Discussion Post Originality Check"  for Turnitin similarity checking. Click on the 'Assignments' link in the course navigation bar to locate the assignment folder. You are required to achieve an acceptable similarity score before posting to the discussion board.  See the Course Resources module's subfolder 'Turnitin' for policy and algorithm (acceptable score) details. 

        Discussion posts placed on D2L prior to Monday morning at 12:01 AM ET are not graded. Post your initial response by Thursday at midnight. Respond to at least one student by Saturday at midnight. Students are encouraged to respond to more than just the 1 required post to promote an engaging classroom experience. Both responses should be a minimum of 250 words, scholarly written, APA formatted, and referenced.  A minimum of 2 references are required (one may be the textbook). Refer to the Grading Rubric for Online Discussion in the Course Resource section.

        Topic III: Men's and Women's Health

        Introduction

        pregnancy and related

        Each medication prescribed during pregnancy and lactation should be scrutinized via drug information resources for adverse effects during pregnancy / lactation, with particular attention paid to the timing of the drug's administration (early, mid, or late pregnancy, or timing of doses in relation to expression of milk/infant feeding). Pre-pregnancy planning is strongly encouraged for patients with chronic conditions and on medications. There is a need to ascertain if there are safer alternative medications available as well as examining the overall necessity of continued therapy during pregnancy.

        All practitioners should be familiar with drugs that are absolutely contraindicated in pregnancy (drugs which have proven teratogenic effects – Category X drugs) and have understaning of how medications are classified (i.e. fetal risk) based on the former Category Ratings and the Pregnancy and Lactation Labeling Rule (PLLR)

        Many common medications include classes such as statins, ACE inhibitors/ARBs, many anticonvulsants, isotretinoin, lithium, NSAIDS, and warfarin (See Table 48-3 in PPP).  Women of childbearing age should be counseled on possible pregnancy consequences if they take these drugs.

        Medication use during pregnancy and lactation is challenging – patients with chronic conditions must be managed and acute issues requiring medication must be addressed as well.  Patients must also be counseled with regard to over the counter medication use during pregnancy and lactation.  Although many of these patients are also managed by specialists in obstetrics / gynecology, primary care practitioners should be familiar with the chronic and acute medications which pose risks in pregnancy and lactation.

        There are many options available for medical contraception.  Women may require a trial of several hormonal contraceptives before they find an option that is ideal for them.  Clinicians may streamline medications by choosing OCs that are approved for additional indications (acne control, etc.).  Choice of combined OC may be based on regimen that patient prefers (cyclic versus continuous).

        Many drugs may interact with hormonal contraceptives and alter efficacy.  Common interactions include antibiotics, steroids, and anticonvulsants.  Hormonal contraceptives may also affect other medications as well. Patients should be counseled and interactions should be checked whenever a new medication is added to a patient on hormonal contraceptives (particularly oral formulations)

        menopause

        For older women, long term use of hormone replacement therapy for  menopause is associated with more overall risk than benefit and should not be used.  Short term hormonal therapy can be useful for patients with bothersome vasomotor symptoms, although should be prescribed at the lowest possible dose and for the shortest possible duration.  Hormone replacement therapy should not be continued for any other purpose (eg. prevention of osteoporosis). Topical estrogen products (not transdermal systemic) with limited systemic absorption may be useful for women experiencing vulvovaginal atrophy.

        Nonhormonal therapies can also be considered in those women for whom estrogens can not be used. Nonhormonal therapies for alleviation of vasomotor symptoms include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), clonidine, and gabapentin

        American College of Obstetricians and Gynecologists (ACOG), American Association of Clinical Endocrinologists (AACE), North American Menopause Society (NAMS), and the Endocrine Society conclude insufficient evidence to support the use of herbal remedies for vasomotor symptoms associated with menopause due to inconsistent results in trials

        Mens health 

        Erectile dysfunction (ED) is defined as the persistent inability to achieve or maintain an erection sufficient for sexual intercourse

        Patients with erectile dysfunction (ED) should be carefully assessed for cardiac function  prior to beginning medical therapy with PDE5 inhibitors (sildenafil, etc.).  (See PPP Table 51-3)

        For men, erectile dysfunction may be worsened by a variety of diseases and drugs.  Treatment should always look to remove or modify potential contributing factors (including offending medications) before drugs are prescribed.  First line treatment with PDE5 inhibitors is usually preferable for most patients due to ease of oral dosing and convenience.  Second line therapies including injections and intraurethral pellets should probably be managed by a specialist. (See PPP Table 51-1, 51-2 ).

        · All PDE5 inhibitors appear to have similar efficacy for treatment of ED.

        · Up to a third of patients will not respond to therapy with PDE5 inhibitors. To achieve the greatest effect, patients must be fully informed of the onset and duration of effect, impact of high-fat meals, the need for sexual stimulation, and explanation that a single trial is not adequate. It is estimated that six to eight attempts with a medication and specific dose may be needed before successful intercourse

        Testosterone replacement has limited role in treatment of ED, and should not be offered routinely to older men in without other clinically significant symptoms and low testosterone levels.  

        BPH can be managed conservatively in the mild to moderate stages, and drug therapy can be started and escalated as the patient's symptoms worsen. Keep in mind that 5a reductase inhibitors will not provide immediate benefits for the patient. Patients on drug treatment for BPH should be monitored for adverse effects including hypotension and sexual dysfunction.

        Medical management should be utilized for patients with moderate to severe BPH with bothersome symptoms, and should initially consist of alpha 1 blockers (alfuzosin 10 mg, doxazosin 2-8 mg, tamsulosin 0.4-0.8 mg, terazosin 2-10 mg, or silodosin 8 mg orally once daily).  5a-reductase inhibitors should be utilized for patients with larger prostate sizes and/or elevated PSA values.  These two medication classes can be combined for patients with severe voiding issues. 

        Alpha 1-blockers are similar in efficacy within the medication class, as are 5a-reductase inhibitors. Older alpha blockers require titration to avoid orthostasis, an adverse event avoided with the use of uro-selective agents.

        Objectives

        At the completion of this module the student will be able to:

        · See "Learning Objectives" outlined in chapters 48-52 of Pharmacotherapy: Principles and Practices

        · Recognize common drugs that are absolutely contraindicated in pregnancy (category X).

        · State the appropriate course of action for checking the appropriateness of medications prior to prescribing medication to women who are pregnant or nursing.

        · Recognize the drugs commonly causing interactions with hormonal contraception which may affect efficacy.

        · State the appropriate uses of hormonal replacement therapy and topical hormonal therapy for menopausal/post-menopausal women.

        · Recognize medications which may contribute to ED.

        · Suggest a first line treatment plan for ED and BPH.

        Readings 

        Pharmacotherapy Principles and Practice

        · Chapter 48: Pregnancy and Lactation: Therapeutic Considerations

        · Chapter 49: Contraception

        · Chapter 50: Menopause and Menstruation Related Disorders

        · Focus on Menopause only for this course

        · Chapter 51: Erectile Dysfunction

        · Chapter 52: Benign Prostatic Hyperplasia

        Other Resources

        · Dynamed Summary for Oral Contraceptives:  https://www-dynamed-com.wilkes.idm.oclc.org/drug-review/oral-contraceptives

        · Dynamed Summary for Hormone Replacement Therapy (HRT):  https://www-dynamed-com.wilkes.idm.oclc.org/management/hormonal-replacement-therapy-hrt-for-menopause-and-perimenopause

        · Dynamed Summary for Erectile Dysfunction (ED):  https://www-dynamed-com.wilkes.idm.oclc.org/condition/erectile-dysfunction

        · Dynamed Summary for Benign Prostatic Hyperplasia (BPH):  https://www-dynamed-com.wilkes.idm.oclc.org/condition/benign-prostatic-hyperplasia-bph

        Videos

        · Impact of pregnancy on pharmacokinetics of medications (Mary F. Hébert, Pharm.D., FCCP): 

        · Erectile Dysfunction (osmosis):

         

        Module III

        Discussions & Assignments 

        Platinum Essays